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KMID : 1007520090180020552
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Food Science and Biotechnology
2009 Volume.18 No. 2 p.552 ~ p.555
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Dandelion (Taraxacum officinale) Flower Ethanol Extract Inhibits Cell Proliferation and Induces Apoptosis in Human Ovarian Cancer SK-OV-3 Cells
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Choi Eun-Jeong
Kim Gun-Hee
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Abstract
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This study investigated the proapoptotic effect of ethanol extracts obtained from dandelion (Taraxacum officinale)flower on human ovarian cancer SK-OV-3 cells. Cells were treated with dandelion flowers ethanol extract (DFE) ranging from1.5625 to 100μg/mL for 24hr. Significant antiproliferative effects of DFE were first observed from at 6.25μg/mL (p<0.05),and this inhibition showed in a dose-dependent manner. When cells were treated with more than 6.25μg/mL DFE, cell-cycleanalysis showed that DFE caused an increase in the percentage of sub-G0/G1 cells and arrested at the S and G2/M phase in adose-dependent manner. Moreover, apoptosis induction by DFE involved p53 activation and bax upregulation as well asdownregulation of bcl-2. Our findings indicate that DFE resulted in apoptotic cell death, suggesting that DFE possessespotential anticancer properties.
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KEYWORD
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dandelion, Taraxacum officinale, apoptosis, cell proliferation
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